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Cystic fibrosis is a frequently fatal condition causes by homozygosity for a recessive allele of the...

Cystic fibrosis is a frequently fatal condition causes by homozygosity for a recessive allele of the CFTR gene. If the allele frequency in the US population is 0.00006, what is the expected frequency of this disease in a large, randomly mating population? What is the expected frequency among children of first cousin marriages (draw the pedigree)? What is the expected frequency among children of second cousin marriages? With this information, how much more likely is cystic fibrosis to occur in children from first and second cousins versus unrelated individuals? How would your answer change if the ancestors were also inbred with F0=0.005?

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Cystic fibrosis is a progressive genetic disorder that cause persistent lung infection and limits the ability to breathe over time, cystic fibrosis found to be happen due the mutation in the CFTR gene (cystic fibrosis transmembrane conduction regulator).

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