Why is methicillin-resistant Staphylococcus aureus (MRSA) methicillin-resistant? Answers are either: -The bacteria are able to prevent...
Why is methicillin-resistant Staphylococcus aureus (MRSA) methicillin-resistant? Answers are either: -The bacteria are able to prevent entry of the drug into the cell. -It produces a modified penicillin binding protein (PBP) target molecule that is not effectively inhibited by the drug. -It has an enzyme that destroys methicillin. -It actively pumps the antibiotic out of the cell.
Homework Answers
B. It produces a modified penicillin binding protein target molecule
- MRSA is due to presence of mecA gene. It codes for modified penicillin binding protein that has low affinity for beta lactams like methicillin. Beta lactams act by binding to penicillin binding protein and prevent crosslinking of peptidoglycan. In MRSA, the penicillin binding proteins are modified so their affinity to beta lactam decreases, therefore they can not prevent cross linking of peptidoglycans and bacteria survives.
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