Describe macrophages and dendritic cells, including where they are located in the host , their primary functions and how they perform these functions? How do macrophages and dendritic cells differ in overall function?
Macrophages-- are phagocytes derived from blood monocytes. Monocytes that migrate into tissues in response to infection can differentiate into specific tissue macrophages. Following migration of monocytes from the blood to various tissues they they undergo for the differentiation into a variety of histological forms. Eg. Kupffer cells in the liver, osteoclasts in bone. They use the process phagocytosis to to process the antigen .
Dendritic cells.- they are bone marrow-derived cells that arise from both the myeloid and lymphoid lineage. There are many type of dendritic cells. Despite their difference is they all constitutively Express high level of class II MHC molecules , and act as potent antigen presenting cells. Dendritic cells acquire antigen by phagocytosis, the antigen is processed and mature dendritic cells present it to the T helper cells. They are located In the specialized tissues.
Dendritic cells present antigen to other cells to kill them while macrophages kill them and then present their peptide to other cells for further help.
Describe macrophages and dendritic cells, including where they are located in the host , their primary...