Question

Explain the logic of this pathway regulations:

Citrate inhibits the citric acid cycle and activates acetyl-CoA carboxylase

Answer 1

Acetyl CoA + oxaloacetate = citrate
(citrate synthase)

-Acetyl CoA and oxaloacetate in the presence of citrate synthase results in the formation of the citrate.
-Increase in the citrate concentrations results in the increase in the product concentrations then according to the law of mass action this increase in product concentration have negative feedback on the enzyme and due to which enzyme citrate synthase is gets inhibited.
-Due to inhibition of the citrate synthase the concentrations of the acetyl CoA increases and results on the activation of the acetyl CoA carboxylase.
The acetyl CoA under the action of acetyl CoA carboxylase results in the formations of malonyl CoA. formation.