Rapsyn, 43 kDa receptor-associated protein of the synapse, is a
protein encoded by rapsn gene.
The protein has camp-dependent protein kinase phosphorylation
site.
Rapsyn is necessary for postsynaptic differentiation. This receptor
protein is
a cytoskeletal protein which interacts with AChR and localizes AChR
to postsynaptic membrane. This localization is very crucial for
developing neuromuscular junctions and for the proper development
of nerves. In the absence of Raspyn, failure of AChR at post
synaptic junctions resulted in aberrant growth of nerves.
What is the role of Rapsyn in the development of the neuromuscular post-synaptic differentiation?