Question

Blood tests found elevated levels of lactate and pyruvate. You may or may not have also discovered that enzyme tests found elevated levels of lactate dehydrogenase (LDH) as well. What is a possible explanation for the elevated levels of all three molecules?

A) Because this man’s PDH enzymes are functioning deficiently, these enzymes require more pyruvate to function efficiently. LDH catalyzes the conversion of lactate to pyruvate, thereby elevating pyruvate levels in an attempt to counteract PDH deficiency

B) Because this man’s PDH enzymes are functioning deficiently, there is a metabolic buildup of pyruvate. More LDH is produced to deal with the excess pyruvate. LDH catalyzes the conversion of pyruvate to lactate, thereby elevating lactate levels

C) Because this man’s PDH enzymes are functioning deficiently, these enzymes require more oxygen. Their consumption of oxygen creates a less oxygen rich environment elsewhere. More LDH is produced to catalyze anaerobic lactic acid fermentation. LDH catalyzes the conversion of pyruvate to lactate, thereby elevating lactate levels

Answer 1

B) Because this man’s PDH enzymes are functioning deficiently, there is a metabolic buildup of pyruvate. More LDH is produced to deal with the excess pyruvate. LDH catalyzes the conversion of pyruvate to lactate, thereby elevating lactate levels

Increase amount of pyruvate is converted to to acetyl CoA in aerobic conditions in presence of oxygen but due to deficieny of LDH enzyme pyruvate is converted to lacate in anaerobic conditions which is done by pyruvate dehydrogenase enzyme with increasing concentration of conditions more amount for PDH enzyme is generated and excess lactate is converted back to glucose through gluconeogenesis.