Question

Examining the Effects of Chemical Modifiers on Heart Rate

1. Describe the effect that pilocarpine had on the heart and why it had this effect. How well did the results compare with your prediction?

2. Atropine is an acetylcholine antagonist. Dos atropine inhibit or enhance the effects of acetylcholine? Describe your results and how they correlate with how the drug works. How well did the results compare with your prediction?

3. Describe the benefits of administering digitalis.

4. Distinguish between cholinergic and adrenergic chemical modifiers. Include examples of each in your discussion.

Answer 1

1) pilocarpine is a alkaloid colinergic agonist drug ,it is Muscarinic receptor agonist .it cause parasympathetic activation and thus decrease heart rate - bradycardia.

It has action paradoxical on cvs , expected effect of Muscarinic agonist is vasodepression but it cause hypertension. Bradycardia and trachycardia both has been reported with pilocarpine