Question

how does the secretion of atrial natriuretic peptide lead to the production of salty urine?

Answer 1

Ans. Vasodilation of the afferent arteriole of the glomerulus is stimulated by the atrial natriuretic peptide(ANP) resulting in an increase in renal blood flow and glomerular filtration rate. When the glomerular filtration rate increases the volume of excretion of urine and water is also increase

In the cortical region and inner collecting medullary duct, sodium reabsorption and renin secretion is inhibited by the ANP, therefore angiotensin II production also decreases which limit the effect of angiotensin II reabsorption of sodium on proximal tubule

Atrial natriuretic peptide act at many sites in the kidney and decreases the left atrial pressure and blood pressure resulting increase in renal salt excretion.

For example, atrial natriuretic peptide (ANP) is a small peptide secreted by the heart upon atrial stretch and high systemic blood pressure. The acute effects of this potent, short-lived peptide include increased glomerular filtration and increased renal excretion of sodium and water.

Its main function is to lower blood pressure,

control electrolyte homeostasis.

ANP inhibits ACTH release and arginine vasopressin secretion

Vasopressin enhances ANP synthesis while GH decreases it.