Question

. The following table summarizes the genotypic data for a single locus from a genomewide association study (GWAS) involving 2500 participants with a specific disease (“cases”) and 7500 healthy “controls”. Based on these data, what would the researchers conclude? Is this marker likely linked to a genetic variant that affects the probability of developing this disease? If so, which allele is associated with higher disease risk?

Genotype Cases Controls

GG 1620 6480

GT 810 990

TT 70 30

Total 2500 7500

Answer 1

Answer:

The general incidence of this disease expanded significantly with the quantity of T alleles which are present within this genotype.

G genotype was most commonly found genotype within the populace analyzed, however the illness demonstrates an a lot high incidence on people having GT genotype and significantly higher on individuals with genotype TT.

Henceforth, we can conclude that if T allele is present inside the genotype, the person will be having expanded shot for the disease to occur.

Patients having genotype GG will have a incidence of 25%,and persons with GT will have a occurrence of 80% and persons with TT will have incidence of 210% when contrasted with normal.

Truly, it appears probable that the marker is very likely connected to a hereditary variation that influences the likelihood of building up this disease.

A very high risk is associated with allele T .