Which of the following immune system mechanisms are most likely inhibited by CD59 (protectin)?
Release of immunoglobulin A (IgA) into the colostrum of breast milk
Reactive oxygen species-mediated destruction of pathogens in the macrophage
Attraction of CD8 T cells to MHC Class I antigens
Proliferation of neutrophils
Membrane Attack Complex (MAC)-mediated cellular lysis
Answer : Membrane Attack Complex (MAC)-mediated cellular lysis
CD59 glycoprotein also known as Mac inhibitory protein ( MAC-IP), membrane inhibitor of reactive lysis(MIRL) or protectin is a protein in humans that is encoded by the CD59 gene.
CD59 attached to host cells via glycophosphotidylinositol (GPI) anchor. It may also signal the cell to perform active measures such as endocytosis of the CD59-CD9 complex. Viruses such as HIV and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement.
Which of the following immune system mechanisms are most likely inhibited by CD59 (protectin)? Release of...