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If you substituted serine for alanine in a protein, how much change to the protein's structure...

If you substituted serine for alanine in a protein, how much change to the protein's structure would you expect?

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The structure of the protein will be drastically changed as serine make the contribution in making electrostatic and hydrogen bonds whereas alanine makes hydrophobic bonds in the protein structure. Thus the secondary structure of the protein will be changed.

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