Question

You are developing compounds to selectively alter monoamine signaling. For each of the following goals, describe the mechanism(s) that could be targeted to produce the desired effect. For each answer, be sure to explain how and why that mechanism would produce the desired effect.

a) Reduce all catecholamine synthesis.

b) Reduce Norepinphrine synthesis without affecting dopamine.

c) Reduce the degradation (breakdown) of catecholamines, but not serotonin.

d) Prevent the synthesis of serotonin without affecting diet or norepinephrine.

Answer 1