Question

Base analogs are mutagenic because of which characteristic?

		They chemically modify the normal bases.
		They distort the structure of DNA.
		They are similar in structure to the normal bases.
		They produce changes in the DNA polymerases that cause it to malfunction.

Answer 1

Base analogs are mutagenic because They are similar in structure to the normal bases.

base analogs are chemical structure which mimic the natural nucleotide of nucleic acid and incorporate in nucleic acid and replace original nucleotide . this replacement result in mutation in DNA and the rate of mutation is higher in base analogs.

example

2-aminopurine is adenine analog and can bind with T or C

5-Fluorouracil is analog of thymine and inhibitor of thymidylate synthetase, etc