Question

in order to be absorbed by the body, many pharmaceutical agents like acetylsalicylic acid must be able to diffuse across cell membranes in the digestive tract. acetylsalicylic acid has a pk of 3.5. the ph in the stomach lumen is 2.5, whereas the ph in the duodenum Lumen is 7.2. use the Henderson-Hasselbalch equation to calculate the ratio of ionized to unionized aspirin at ph 2.5 and 7.2

Answer 1