Question

Part A The reduction of rNDP by RNR is a chain of consecutive reactions. Using the figure and your knowledge of the mechanism, identify the correct order of these steps 0 0 H20 START OH OH OH OH OH OH 0 441 SH 0 Y122 SH 0. 0. OH H OH OH H r Rank the steps from the first to the last. To rank steps as occurring at the same time, overlap them. View Available Hint(s) Reset Help Reduction of Reduction of Glu-448 takes a proton from Cys-225Regeneration C-2 Creation Creation ofMigration of free radicala thiyl radical and creation f of C-3 radical anion radical of a radical radical a radical and Cys-462 by Grx by disulfide a on Tyr-122 disulfide at C-3 at Cys-439 to C-2 anion a free radical First step of cycle: presence of a radical at Tyr-122 Last step of cycle: initial state re-established

Answer 1

According to my knowledge , the above reaction steps are in the correct order. Firstly, there is creation of free radical at Tys then free radical generated at C-3. Then reduction at C-2 and creation of disuphide radical anion.

Fourth step is the reduction of radical at C-3 by disuphide anion.

fifth step is regeneration of free radical at Tys.