Question

ure I was converted to quinine (A), other compounds were formed, 4. When structure I was converted to ou including compound D. HO Н. HO H.co Ho-o a) There are carbon stereocenters in structure D. Assign the R and S configuration at each stereocenter of D.

Answer 1

solution: R- Referring s- Sinister Rectus he clock wise rotation, he antic lock wise rotution. Configuration: Spatial arrangement of the atoms of a chirul molecular entity and its stereochemical description. Rule: 1) Highest atomic number first priority 2) Two substituents with equal rank, proceed two along the substituent chain until there is a point of difference and then give highest atomic number first priority. 3) Put lowest priority substituent in the back ( dushed) line) 4) Highest priority - in front ( wedged line) s fro Proceed from 1 to 2 to 3 6) Determine direction, 1) clockwise - R - Anticlockwise-s If lowest priority group then reverse from R R to s above or the plane are front s to R.

solution: The given reaction is 4 HO HH И , theo in structure D @ There are four (4) carbon stereo centres # R and s configuration of stereocentre of D. Carbon a s configuration, Carbon 2-s configuration carbon 3-R configuration Carbon 4-R s configuration