Question

1. Complete the flowchart below for the following extraction:

Benzoic acid 4-aminoacetophenone benzophenone

Step 1: Dissolve in ethyl acetate

Step 2: Add 2M NaOH

Step 3: Mix and Identify how layers separated:

DRAW STRUCTURES IN THE CORRECT FORM AT THAT STEP (neutral? Salt? etc)

AQUEOUS ORGANIC

Step 4: Add 3 M HCL

DRAW STRUCTURES OF COMPONENTS IN AQUEOUS LAYER

Step 5: Collect with vacuum filtration

DRAW STRUCTURE OF COMPONENTTS

2. Write a balanced chemical equation for each reaction which occurs in the flow chart above. All structures must be drawn out (nonzero formal charges included).

3. If you were to use hexane and water for this extraction, what would happen? A layer of solid is suspended between the two layers. What is it and why is it ont dissolving in either layer? Is hexane a good solvent choice? Why/why not?

4. Would acetone and water be a good solvent for an extraction?

5. What is the best method in terms of time necessary to perform, difficulty, or any other factors-- recrystallization, column chromatography, or extraction?

Answer 1

Flow Chow Souble in the wall NOOH ORGANIC Aqueous phas e 0-wonat J.HU 0.0" + Naci (aq) evaporation g'ERA (ethyl aurare) using Rota vapor Pure NH₂ to 4 vacuum filharson (TwoH Nace(aq) (solid) Ques-3 Hexane is NON Polar holwent and benzoic aud and 4- amincalutophe none aue Pelar Organic compound Sonce like dissolve like (Above two compounds Remain Insptuele in Hexane So Hexane Not a good choice. Polar solvent should be used

-Look Cromo s Jun engautare Both are soluble in ethyl acreete Quis-9 - Chemical Reawi ong after addition of Naon To Look + NaOH Salt TO DONA + H2O Salt formation bodium benzo an (Soulle in Aqueous Phase) •Remains in Organic phase a seprared using in Aqueous phases I sepraving funnel -wonat is Now addition of HCP To-coonat it Htce Na (07-00H + Naci) (aq) Oude produit (ppt) Distanded can easily be seprated using Vaccum fitratton

Sues 4 * Acetone and warere cannot be used fou exhaution alone . For aid Base extraction am NaO HI HA are needed More awe mostly autone Not used because they 4 95 complerley mes uble with water so No auration would take place . So - Autone & water cannot be used