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Probenecid is a drug that acts as a renal tubular blocking agent. If taken in combination with another drug it can reduc...

Probenecid is a drug that acts as a renal tubular blocking agent. If taken in combination with another drug it can reduce the tubular secretion of the other drug. Therefore, probenecid can be intentionally prescribed with an antibiotic, for example, to ____________ its plasma concentration and to ____________ its therapeutic effect, compared to that of the antibiotic treatment alone.

decrease; prolong

increase; shorten

increase; prolong

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Answer: Increase, prolong.

The probenecid can be intentionally prescribed with an antibiotic, for example, to increase its plasma concentration and to prolong its therapeutic effect, compared to that of the antibiotic treatment alone.

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