Question

2. While caffeine is very soluble in water, aspirin is only minimally soluble. a. Clearly explain why you think caffeine is soluble in water. b. In order to dissolve the aspirin, I had to use a sodium hydroxide solution (this is why you had to add HCl to the separatory funnel.) Clearly explain how the use of a sodium hydroxide solution allowed the aspirin to dissolve. Structures/reaction(s) will likely help your answer.

Answer 1

Q-2 Answer (a) caffeine is soluble in water because water can Hydrogen bond to caft eine at six different places. The Hydragen of the H2O molecule is attracted to the Highly electronegative 'N" and "0" atoms of a caffeine. s- St stou non 7 0 NS- S + oh St St. + Figi 6 places where Hydrogen tond formed with H₂2 The reason why aspirin is minimally in H2O souble i te cause of its Hy drophobic of the molecule. porton Ano, the cartox flic Hydrogen on acid the tune tianod Intramolecular group con form Hydrogen bond making with it exter even group further den somete in H2O s-anunst Hydrophobic Porsion Intramolecular Hydrogen band

Naon ONG weak electrolyte Strong electroeste after reaction with NaOH Intram ad ecular Hydrogen tond vanished and He ion DI replaced by Nation this making Aspirin a strong electrolite which dissolved in H2O easily.