Question

In the following reaction sequence, draw the inter

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Concepts and reason

The organic reactions involve the conversion of one or more functional groups to other useful functional groups using wide range of reagents.

Fundamentals

Claisen condensation:

The claisen condensation is a named organic reaction. It is used to form a new carbon-carbon bond between two esters having alpha hydrogens in the presence of strong base such as an alkoxide base in alcohol, resulting in the formation of beta-keto ester.

1) NaOR, ROH
1
-hablan
R2-
R1
+
R1-OH
2) H30+
R2
R2
ester
beta-keto ester
alcohol

Acetoacetic ester synthesis:

The acetoacetic ester synthesis is a useful reaction for synthesizing ketones from alkyl halides in the presence of strong base such as an alkoxide base in alcohol.

1) R2
RX
+
ROH + C0
2) NaOR4, R4OH
3) RX
4) H,0, H,0*, heat
مه

EtOH
لے
لی
.لز
»
و
/
+
o
H,0*
OH

- EtOH
BrPcHz a
- EtOH
တွင်-
H,O, H,Of, heat
- CO2, EtOH

Ans:

1) NaOEt,
EtOH
2) H30+
3) NaOEt, EtOH
4) C6H3CH Br
5) NaOEt, EtOH
6) CH3Br
7) HO, H307, heat

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In the following reaction sequence, draw the intermediate formed after the first two steps, then select...
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