Question

Enantiomers have the same physical properties and cannot be separated using typical laboratory methods. One method of separating a racemic mixture is to use chiral column chromatography. Select the true statements below. There are 2 true statements.

1. the column converts one of the enantiomers to the other

2.a chiral solvent is used in chiral chromatography

3.a chiral absorbant is used in chiral chromatography

4.one enantiomer will elute faster than the other

Answer 1

Chiral column chromatography: In this chromatography, the stationary phase contains a single enantiomer of a chiral compound The two enantiomers of the same analyte compound varries in affinity to the single -enantiomer stationary phase, hence they exit the column at different times The two true satements are as follows: 3. A chiral absorbant is used in chiral chromatography. The stationary phase is composed of a chiral absorbant in order to recognize the chirality of the analyte. This will create attractive forces between the bonds and also form inclusion complexes 4. One enantiomer will elute faster than the other. The two enantiomers of the same analyte compound differ in affinity to the single-enantiomer stationary phase, so they exit the column at different times. Thus, one enantiomer will elute faster than the other.