Question

Chapter 16 Reading Question 4

Part A

Which regulatory effects are results of internalized cholesterol?

1) It activates acyl-CoA:cholesterol acyltransferase.
2) It increases endogenous cholesterol synthesis.
3) It downregulates the production of LDL receptors.
4) It inhibits HMG-CoA reductase.

Which regulatory effects are results of internalized cholesterol?

1) It activates acyl-CoA:cholesterol acyltransferase.
2) It increases endogenous cholesterol synthesis.
3) It downregulates the production of LDL receptors.
4) It inhibits HMG-CoA reductase.

Statements 1, 2, and 4 are direct results of the internalization of cholesterol.

Statements 2, 3, and 4 are direct results of the internalization of cholesterol.

Statements 1, 3, and 4 are direct results of the internalization of cholesterol.

Statements 1 and 4 are direct results of the internalization of cholesterol.

Answer 1

Answer - C - Statements 1, 3, and 4 are direct results of the internalization of cholesterol.

Internalized cholesterol increase means,

It decrease the production of low-density lipoprotein (LDL) receptor and HMG-CoA reductase.

Normally HMG-CoA reductase leads to an increase of endogenous production of cholesterol.

But due to internalized cholesterol HMG-CoA reductase inhibits so, endogenous production of cholesterol decrease. So statement 2 is not possible.