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How do the hormones (insulin, glucagon, epinephrine, and cortisone) regulate metabolism? What are the roles of...

How do the hormones (insulin, glucagon, epinephrine, and cortisone) regulate metabolism? What are the roles of enzymes or vitamins?

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Ans) Glucoregulatory hormones include insulin, glucagon, amylin, GLP-1, glucose-dependent insulinotropic peptide (GIP), epinephrine, cortisol, and growth hormone. Of these, insulin and amylin are derived from the β-cells, glucagon from the α-cells of the pancreas, and GLP-1 and GIP from the L-cells of the intestine.

- Insulin stimulates glycogen, fat and protein synthesis in all target tissues (including liver) and modifies gene expression, but the effects vary between tissues. Exercising muscles can take up glucose from the blood in the absence of insulin.

- The fundamental purpose of enzymes is to facilitate reactions by lowering this activation energy. Coenzymes, some of which are vitamins and some of which are synthesized directly from vitamins, activate enzymes by helping the enzyme to bind to its substrate.

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