3 concept maps Anemia - Sickle cell, Acid Base - Thombcytopenia) - what to talk about...
3 concept maps
Anemia - Sickle cell,
Acid Base -
Thombcytopenia) -
what to talk about Patho, RISK factor, complications, symptoms, treatment)
Homework Answers
Sickle cell anemia is a type of anemia in which red blood cells become sickle shaped due to deficiency of oxygen and blocks the blood vessels . Metabolic acidosis occur in sickle cell anemia and platelet count decrease in splenic sequestration.
Pathophysiology :-
Deoxygenation leads to polymerization of hemoglobin . It leads to sickling of red blood cells causing endothelial damage,which further leads to vasoconstriction ,organ ischemia and end organ damage .
Risk factor :-
- low oxygen tension
- infection
- dehydration
- acidosis
- concomitant disease like sarcoidosis, herpes etc
- extreme physical exercise
- alcohol
- pregnancy
- physiological stress
- cold weather
Complications :-
-avascular necrosis
- pulmonary artery hypertension
- sickle nephropathy
- ocular disease
- iron overload
- leg ulcers
- stroke
- acute chest syndrome
- chronic hemolytic anemia
- splenic sequestration
Signs and symptoms :-
- rapid heart rate
- breathlessness
- delayed growth and puberty
- jaundice
- fatigue
- attacks of abdominal pain
-vomiting
- joint pain
- hematuria
- excessive thirst
- chest pain
- decreased fertility
- priapism
Treatment :-
The main four treatment options are :-
- blood transfusion
- drug treatment
- gene therapy
- blood and marrow stem cell transplantation
Treating strategies are :-
- management of vaso- occlusive crisis by providing oxygen .
- management of chronic pain syndrome by providing analgesics.
- management of chronic hemolytic anemia.
- prevention of infections and treating infection with antibiotics.
- management of complications .
- prevention of stroke , detection and treating pulmonary hypertension.
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3 concept maps
Anemia - Sickle cell,
Acid Base -
Thombcytopenia) -
what to talk about...
do 3 concept maps (Anemia - Sickle cell, Acid Base - all 4, Thombcytopenia) - Patho,...
do 3 concept maps (Anemia - Sickle cell, Acid Base - all 4, Thombcytopenia) - Patho, Risk factors, complications, symptoms, treatment)
do 3 concept maps (Anemia - Sickle cell, Acid Base - all 4, Thombcytopenia) - Patho,...
do 3 concept maps (Anemia - Sickle cell, Acid Base - all 4, Thombcytopenia) - Patho, Risk factors, complications, symptoms, treatment)
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Which of the following statements about sickle cell anemia is INCORRECT? Select one: a. Prenatal diagnosis of sickle cell anemia can be made by examination of DNA from fetal cells obtained by amniocentesis. b. Red cells have a shorter than normal survival in the circulation c. No treatment is available. d. Newborn infants homozygous for the sickle cell gene have few symptoms because their red cells also contain a large amount of fetal hemoglobin as well as sickle cell hemoglobin...
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