Question

Sickle-cell anemia is caused by a single point mutation in the hemoglobin of human red blood cells. It is a recessive gene. People who have sickle cell anemia are homozygous recessive and suffer terribly from this disorder. Now I have stated in lecture that mutations are neither good nor bad. Rather it depends on how the mutation effects the survival of the species. If the mutation harms the survival of the species it is bad, if it helps the survival of the species it is good. Now tell me is this mutation good or bad?

Answer 1

Sickle cell anemic is a bad mutation in which 6th position of the beta polypeptide chain glutamic acid changes into the valine by which red blood carpuscles changes into the sickle shape bye which they can not tranport oxygen and haemoglobin destroyed and will exudate from the cappillaries by which anemia occur.In this disease person will no longer survive,maximu of 20 years person survive.