Question

Question 3 1 pts The best description of how allosteric regulation works is that a ligand ___the transcriptional regulatory protein, which the protein's affinity for DNA. O binds to; causes conformational changes that can only decrease O covalently modifies; increases O covalently modifies; decreases O binds to; causes conformational changes that affect

Answer 1

The answer is as follows-

The concept of allosteric regulation is that the ligand never binds to the original binding site of the protein or enzyme.In allosteric regulation,substrate binds at a different site and ligand binds at a different site.The binding of ligand cuases a conformational change in the protein or enzyme due to which the original binding site of substrate is disrupted in its configuration due to which substrate fails to bind.However it is important to note that there are examples of allosteric regulation where the ligand potentiates the activity of enzyme or protein as seen in case of drugs like benzodiazepines acting on GABA receptors.Hence the answer should be the last option-binds to;causes conformational changes that affect..

Amswer a losteric Binding Bregulator allosteric Site K 12 → porotein) enzyme → Substrate binding site A substrate Positive modulation Negative modulation conformational change Conformational Ghange + More accurate gap Migand do substrate fits easily Substanate Jols to fit Caudily