![13. In a few words each, describe one of the 2 the features of the ITAM that make it perfectly suited to bind tandem SH2 domains. [2 pts]](http://img.homeworklib.com/questions/3383c650-bff9-11ea-99bf-0bc1ae5566ea.png?x-oss-process=image/resize,w_560)
Homework Answers
The characteristics of this binding is featured by T cell receptor CD3 epsilon subunit of the ITAM. The main feature of this peptide subunit which aids in the binding is its affinity rate of 18-81 nM at 150mM NaCl over the 4.5 - 30 degrees centigrade temperature range.The temperature dependence plays a key role. The two features are:
- This helps in the on rate constant for the increase in the affinity of binding.
- The fluorescence of Syk-tSH2 and its CD3 epsilon peptide comples.
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