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Do MHC class II receptors have all contents of the cell presented on them?

Do MHC class II receptors have all contents of the cell presented on them?

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MHC class II molecules are a class of major histocompatibility complex (MHC) molecules found on relatively specialized immune cells such as dendritic cells, B cell , macrophage and thymic epithelial cell .

Only extracellular antigens are presented by class II MHC

The Basic sequence of its function are:

  • First a extracellular pathogen is phagocytosed and surrounded by a phagocytic vesicle.
  • A lysosome with proteases fuses with the phagocytic vesicle and then degrade the pathogen into small peptides
  • Meanwhile MHC II molecule is synthesized in the rough ER.
  • Vesicle containing MHC II molecule fuses with the vesicle containing the peptides, and a peptide bind to MHC II molecule.
  • Then exocytosis occurs.
  • The peptide and MHC II molecule are now presented on the cell surface and recognized by a specific T cell receptor on a T cell.

Thus , as exogeneous antigens are presented by class II MHC so MHC class II receptors don’t have all contents of the cell presented on them

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