Question

Explain how Thin Layer Chromatograpy (TLC) was used to monitor the progress of the second step of the diantilis synthesis ( the conversion of the benzyl alcohol into the diantilis product). Illustrate your answer by drawing representative TLC plates.

Answer 1

In the synthesis of daintily second step (benzyl alcohol to ether): the study of progress of reaction is monitored by TLC, the reactant of second step (benzyl alcohol compound) is more polar in nature and its rf value is lower than product formed (daintily), which is ether and less polar compared to benzyl alcohol and its rf value is higher, while studying progress of reaction the unreached benzyl alcohol is monitored till completion of reaction to the product, there are two spots on the TLC plate, the lower (closer to starting line) spot from starting Hne is finally disappeared and only higher spot is visible. mobile phase used is 98: 2 ethyl acetate: acetic acid for better separation. the first the plate is while progress of reaction which shows A = UNRAECTED BENZYL ALCOHOL AND B = AMOUNT OF PRODUCT FORMED in the secon tlc plate there is only spot of product is seen and not the starting benzyl

.B .A ----------

.B    ---------

the first the plate is while progress of reaction which shows A= UNRAECTED BENZYL ALCOHOL

AND B= AMOUNT OF PRODUCT FORMED

in the secon tlc plate there is only spot of product is seen and not the starting benzyl alcohol. this means that

by using tlc conversion of second alcohol is monitored.