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Extra credit for 5 points. Answer any one and only one of the following:


Extra credit for 5 points. Answer any one and only one of the following:


 a. Compare and contrast carbamoylphosphate synthetases I and II.

 b. Discuss the so-called Krebs Bicycle.

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Answer #1

CPS-I:
Cellular location = Mitochondria
Nitrogen donor = Ammonia
Pathway = Urea cycle
Regulation = It is activated by NAG

CPS-II:
Cellular location = Cytoplasm
Nitrogen donor = Glutamine
Pathway = Pyrimidine biosynthesis
Regulation = It is inhibited by CTP


Kreb's bicycle involves the interaction between the TCA cycle and the Urea cycle.
Argininosuccinate produced by the urea cycle results in the formation of Malate that enters the TCA cycle.
Oxaloacetate is produced during the TCA cycle. It is aminated to produce Aspartate. Aspartate combines with Citrulline to produce Argininosuccinate in the urea cycle

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