Which of the following could lead a mutation to express a dominant phenotype? Check all that...

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Which of the following could lead a mutation to express a dominant phenotype? Check all that apply. The affected gene is hapl

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Answer 1

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1- Correct- In some cases, two copies of a gene are required for normal function, so that removing a single copy leads to expression of mutant phenotype. Such genes are referred to as haplo-insufficient.

3. Correct -mutations in one allele may lead to a structural change in the protein that interferes with the function of the wild-type protein encoded by the other allele. These are referred to as dominant negative mutations.

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Answer 2

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