Question

Which of the following statements about mutations are true?

Select all that apply.

Select one or more:

a. Both substitution and indel mutations could result in a non-sense mutation in the affected codon following the mutational event.

b. Indel mutations that occurred in an exon (translated part of the gene) can be silent.

c. A substitution mutation can lead to a frameshift.

d. Mutations are the only source for the origin of new alleles.

Consider the wild-type DNA sequence: ^3' ATACTTTCA ^5'. (Only the transcribed strand is shown).

Which of the following shows an indel mutation of the wild-type DNA sequence shown above that does NOT result in a frameshift mutation?

Select all answers that apply.

(Only the transcribed strand of the mutated sequence is shown. Inserted bases are in bold. Deleted bases are indicated by ' ).

Select one or more:

a. ATA[‘’]TTCA

b. A[‘’’]TTTCA

c. ATTACTTTCA

d. ATA[‘’’]TCA

Answer 1

1. among the following the statements that can apply are -

Both substitution and indel mutation can cause non-sense mutation in affected codon

indel mutation has both insertion and deletion so, yes they can be silent

substitution mutation can cause frame shifts.

The last statement dont apply because there are many other reasons for the origin of new alleles other than mutation.

2. The option will be the 3rd one as all the 3 bases or a complete codon is deleted the reading frame remains the same