Question

Is BRCA1 involved in any mismatch repair systems or linked to certain MMR genes? If yes, what types of diseases or cancers are the interaction associated with?

Answer 1

BRCA1 is basically associated with a genome surveillance complex in addition to DSBR ) which includes mismatch repair (MMR) proteins to sensor and repair replication-associated DNA damage that has run off the DNA polymerase proof- reading mechanism. Mutations in BRCA1 gene are basically related with an increasing risks of breast cancer in both the men and women, as well as many other types of cancer. These mutations are basically present in every cell in the body and can be passed from one generation to the next. Also, the crucial breast cancer vulnerability genes involving in DNA repair, including BRCA1 & BRCA2, have also been recognised. However, the mutations in the genes account for only 5–10% of recognised breast cancer cases. Additionally, DNA repair pathway genes also may contribute to vulnerability.

Mutations in BRCA1 gene are basically related with an increasing risks of breast cancer in both the men and women, as well as many other types of cancer. These mutations are basically present in every cell in the body and can be passed from one generation to the next. Also, the crucial breast cancer vulnerability genes involving in DNA repair, including BRCA1 & BRCA2, have also been recognised. However, the mutations in the genes account for only 5–10% of recognised breast cancer cases. Additionally, DNA repair pathway genes also may contribute to vulnerability. Enzyme responsible for mismatch repair:- A DNA polymerase replaces the missing section with correct nucleotides, and an enzyme called a DNA ligase seals the gap Mismatch repair. A mismatch is detected in newly synthesized DNA.