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5. Which type of particle recognition receptor can detect foreign DNA in the cytoplasm?

5. Which type of particle recognition receptor can detect foreign DNA in the cytoplasm?

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The foreign DNA or genomic viral DNA is detected in the cytoplasm by Vegas or in the nucleus by IFI16. Both sensors activate SITING to induce type- I IFNS. cGAS and RLRs can also detect viral replication intermediates in viral factories.

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