Question

Question 2 (1 point) ✓ Saved To What is the most likely mode of inheritance for this pedigree?

Answer 1

The correct answer is Autosomal and recessive

Explanation; The trait is not dominant because an offspring inherited a dominant allele from its parents, so diseased phenotype tends to appear in every generation. But here diseased phenotype is not seen in every generation so the mode of inheritance in this pedigree can not be dominant. Autosomal means the gene is not on a sex chromosome which is X or Y. In an X-linked pedigree, males are more affected than females because a female offspring inherits one X-allele from her mother and one from her father. So a female offspring is affected only if both the parents carry the disease-causing allele, and an affected female must have an affected father (Males have single X-chromosome which is inherited by their female offsprings). But a male offspring is affected when only the mother carries the diseased allele.

Here in the given pedigree there are skipping of generation (diseased phenotype is not seen in every generation), and affected female progenies don't have affected father. So the mode of inheritance in a given pedigree is Autosomal and recessive.

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