Question

True or false:

a) The electron-withdrawing substituents do not impact the acidity of carboxylic acids.

b) Hydrolysis of nitriles is a method to synthesize carboxylic acid.

c) The order of reactivity of carboxylic acid derivatives is as follow: Acyl chloride > Acid anhydride > Ester > Amide.

d) SOCl2, PCl3 and PCl5 are three types of special reagents to convert carboxylic acid to acyl chloride.

e) Acyl chlorides are the most reactive common acyl derivatives, and can be used to synthesize anhydride, ester, and amide.

f) Acyl chloride is a very stable compound and cannot react with water.

g) Acyl chloride can be reduced by LAH or Grignard reagents to secondary alcohol.

h) Esters are named by naming the alkyl group attached to the oxygen followed by the carboxylic acid’s name with the suffix – ate.

I) The reactivity of carboxylic acids is determined by induction, resonance, sterics, quality of leaving group.

J) Acid anhydrides are the products of two molecules of carboxylic acids under high temperature treatment.