a) What could the amino acid sequence GGGG form? Why? b) could the tertiary structure of...
a) What could the amino acid sequence GGGG form? Why?
b) could the tertiary structure of this sequence contain a β-sheet? If so, which type and why?
Homework Answers
1. The amino sequence GGGG ( gly-gly-gly-gly-) is attached with another amino acid serin. The serin residue is linked with the sequence to give it polar character to the linker. The whole linker is from antibody binding factor. It attached with the helper T cells. This sequence GGGGS , are also called flexible linker. This also used for recognition or tag removal.
2. This sequence is so flexible not to be folded. So this sequence doesn't from tertiary structure. It is hard to form the sequence into tertiary structure and placed to ß plated sheet.
Note that gly and ser residues does not cobtain side chains to form secondary structure.It is best for fold breaking linker to expose fusion protein partner well.
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