Question

There are many different filter materials used in syringe filters. Some of the most common are cellulose acetate (CA), polyamide (PVDF), teflon (PTFE), and polyethersulfone (PES). They all have different compatibility issues. Which material(s) are low protein-binding and suited well for applications involving proteins? PVDF PTFE CA PES

Answer 1

Out of the above four filter materials the following two are low protein-binding and suited well for application involving proteins -
1) Cellulose acetate (CA) - Very low protein binding and are used in processes requiring maximum protein recovery. CA contains some wetting agents which might be harmful for sensitive cells. Therefore, CA is good for filtration of buffers and aqueous reagents. CA are naturally hydrophibic.
2) Polyethersulfone (PES) - PES is naturally hydrophilic. PES is low protein binding and is ideal for tissue culture media sterilization, microbiology fluid applications, clinical and general filtration.

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