The diagram below represents a polypeptide with multiple signal sequences. Which signal sequence will the SRP recognize to initiate translocation in the ER? Why? Sketch the arrangement of the protein in the ER membrane.
Homework Answers
The SRP will recognize the first signal sequence present at the N terminal , as its function is to direct the insertion of thee nascent polypeptide in to the transmembrane channel. proteins are synthesised fro N terminal to C terminal.so nascent polypeptide will bind the SRP towards the signal sequence present near N terminal.
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The diagram below represents a polypeptide with multiple
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The ER signal sequence on a growing polypeptide chain is recognized by a signal-recognition particle (SRP) in the cytosol. What does this interaction accomplish? It cleaves the ER signal sequence from the polypeptide chain. It cleaves the ER signal sequence from the polypeptide chain. It guides the ribosome and its polypeptide to the ER. It releases the polypeptide chain from the ribosome. It speeds the synthesis of the polypeptide chain. Which of the following choices reflects the appropriate order of...
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1. Where is the ER targeting sequence located in the polypeptide chain (N-terminal, interior, or C-terminal)...
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What is the correct order for the following steps in co-translating a soluble protein into the...
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Drag the terms on the left to the appropriate blanks on the right to complete the...
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Problem 4.1.3 (tags: #protein targeting, #protein topology, #transfer sequence) a) Make a map showing the location of signal sequences, start transfer sequences and stop transfer sequences in protein A and protein B below that end up inserted in the membrane as shown. Protein A NH, Cytosol NA J B Scoot & Membrane Protein B COOH HAN Ν - FC ER Cisterna b) Make a map for the arrangement of signal sequences, start transfer sequences and stop transfer sequences for a...
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1. (14pts) A. What are the functions of the signal recognition particle (SRP) and translocon in p...
PLEASE ANSWER ALL THE QUESTIONS IN EACH PART. THANK YOU!
1. (14pts) A. What are the functions of the signal recognition particle (SRP) and translocon in protein transport to the ER? SRP Translocon B. How does the translocon determine which orientation to insert membrane proteins? C. How do budding & fusion affect the orientation of integral membrane proteins during vesicle transport? D. Consider a ligand-gated ion channel at the plasma membrane that binds to ligands in the cytoplasm. From a...
The picture below schematically depicts proteins containing various types of signals and topogenic sequences. Predict the...
The picture below schematically depicts proteins containing
various types of signals and topogenic sequences. Predict the
arrangement of each type of protein shown in the figure with
respect to the endoplasmic reticulum membrane and
lumen. Provide the drawings.
Cleavable signal sequence (a) N Noncleavable = signal-anchor sequence Stop-transfer sequence (b) N4 DNA - C (d) NHH (e) N-
5. (8 pts) The figure below depicts recombinant proteins with various types of signal sequences. A....
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The ER signal sequence on a growing polypeptide chain is recognized by a signal-recognition particle (SRP) in the cytosol. What does this interaction accomplish? It cleaves the ER signal sequence from the polypeptide chain. It cleaves the ER signal sequence from the polypeptide chain. It guides the ribosome and its polypeptide to the ER. It releases the polypeptide chain from the ribosome. It speeds the synthesis of the polypeptide chain. Which of the following choices reflects the appropriate order of...
1. Where is the ER targeting sequence located in the polypeptide chain (N-terminal, interior, or C-terminal) 2. Name 4 organelles that require organelle specific targeting sequences in polypeptide 3. Name 3 final locations for proteins with ER signal sequence 4. Satranslational translocation: (a) Name the protein that the signal sequence binds to (b) Name the protein SRP binds to 5. State the function of signal peptidase 6. Name a membrane protein that is not a single pass membrane protein 7....
What is the correct order for the following steps in co-translating a soluble protein into the ER lumen? #1 Choose... Translocation of the protein through the translocator begins. Signal sequence is cleaved by signal peptidase. ER Signal sequence binds to the translocator channel. SRP binds SRP Receptor. Translation begins. SRP binds ER signal sequence. Ribosome dissociates from ER membrane. Translation of the polypeptide finishes. Ribosome binds mRNA. Translation pauses. Choose.. Choose... Choose... #9 Choose... #10 Choose...
Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Terms can be used once, more than once, or not at all. Reset Help transport vesicle(s) Soon after initiation of translation of an mRNA coding for a secretory protein, the of the secretory protein is synthesized and is exposed on the surface of the ribosome. The signal recognition particle (SRP) contains the that marks this protein for into the endoplasmic reticulum cotranslational translocation...
Problem 4.1.3 (tags: #protein targeting, #protein topology, #transfer sequence) a) Make a map showing the location of signal sequences, start transfer sequences and stop transfer sequences in protein A and protein B below that end up inserted in the membrane as shown. Protein A NH, Cytosol NA J B Scoot & Membrane Protein B COOH HAN Ν - FC ER Cisterna b) Make a map for the arrangement of signal sequences, start transfer sequences and stop transfer sequences for a...
PLEASE ANSWER ALL THE QUESTIONS IN EACH PART. THANK YOU!
1. (14pts) A. What are the functions of the signal recognition particle (SRP) and translocon in protein transport to the ER? SRP Translocon B. How does the translocon determine which orientation to insert membrane proteins? C. How do budding & fusion affect the orientation of integral membrane proteins during vesicle transport? D. Consider a ligand-gated ion channel at the plasma membrane that binds to ligands in the cytoplasm. From a...
The picture below schematically depicts proteins containing
various types of signals and topogenic sequences. Predict the
arrangement of each type of protein shown in the figure with
respect to the endoplasmic reticulum membrane and
lumen. Provide the drawings.
Cleavable signal sequence (a) N Noncleavable = signal-anchor sequence Stop-transfer sequence (b) N4 DNA - C (d) NHH (e) N-
5. (8 pts) The figure below depicts recombinant proteins with various types of signal sequences. A. NH2 COO H B. NH2 COOH ER import sequence mitochondria import sequence C. NH2 ER retention sequence nucleus import sequence COOH .NH2 COO H D. What is the final cellular destination of each protein? A. B. C. D.
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