Question

The venom of the Eastern diamondback rattler and the Indian cobra contains phospholipase A2, which catalyzes the hydrolysis of fatty acids at the C-2 position of glycerophospholipids. The phospholipid breakdown product of this reaction is lysolecithin (lecithin is phosphatidylcholine). At high concentrations, lysophospholipids act as detergents, dissolving the membranes of erythrocytes and lysing the cells. Extensive hemolysis may be life-threatening. Draw the lysolecithin that results when a phosphatidylcholine molecule is exposed to phospholipase A2. Represent any acyl groups as "R." Assume physiological pH. Lysolecithin Select Draw Rings Groups More Erase 71CNOPH BO @ 22

Answer 1

Phopholipase A2 acts on cell membrane and breaks down lysolecithin to produce free fatty acids mostly arachidonic acid.

This arachidonic acid is used to form prostaglandin, thromboxanes, leukotriens. All these substances causes inflammation & edema.

Answer- Option B. ( It can cause the release of arachidonate from lecithin molecule).

Lysophospholipase remove the fatty acid at C-1 of lysolecithin.

Answer- Option A.

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