Question

1. Below are traces of membrane potential (and action potentials) over time of two types of cardiomyocytes: contractile cells and autorhythmic (pacemaker) cells. Note that the x-axes measure time, but are NOT on the same scale. Which one shows the potential changes occurring in pacemaker cells? Explain your choice

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I need to use this graph to answer the questions below. Need ASAP

1. Some snake venoms (produced by cobras and their relatives) block the low voltage-gated, T-type Ca2+ channels on pacemaker cells. On the appropriate axes above, draw a new trace of membrane potential over time, showing how this venom will change membrane potential and action potential frequency. Explain the channel mechanics that underlie your answer.

2. Imagine that a grizzly bear begins chasing you. You respond by secreting norepinephrine (NE), a hormone that binds to pacemaker cells and increases the conductance/permeability of their low voltage-gated (leaky) Na+ channels and T-type Ca2+ channels. On the appropriate axes above, draw (with a dashed line) another trace showing how NE will alter membrane potential and AP frequency over time. Explain the channel mechanics underlying your answer.

3. NE affects L-type voltage-gated Ca2+ channels on contractile cardiomyocytes in a similar manner, by increasing their permeability to Ca2+ ions when they are stimulated. Given this, explain how and why the strength of ventricular contraction will change will change in response to NE.

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Question 1-

1. Below are traces of membrane potential (and action potentials) over time of two types of cardiomyocytes: contractile cells

In the graph, the red line is showing venom effect in the pacemaker cells. This is showing a reduction in length of generating action potential gradually. After some time a prolonged length will observe for exciting the action potential, finally the end up with no action potential.

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