Question

Which of the following is not known

		where membranes in the autophagic pathway nucleate from
		whether COPI/II is directly involved in formation of multivesicular endosomes
		the signals that target plasma membrane receptors to multivesicular endosomes
		why the LDL particle dissociates from the LDL receptor in late endosomes

Answer 1

Answer -where membranes in the autophagic pathway nucleate from - not known.

Reason -Because autophagy is an unselective bulk degradation pathway, the specific membrane origin of all APs remains obscure, though morphological features of APs are basically common to conventional and alternative autophagy

*whether COPI/II is directly involved in formation of multivesicular endosomes - yes ,they are involved.

COP II mediate ER to cis-Golgi

COP I mediate cis-Golgi to ER; Later to earlier Golgi cisternae

*the signals that target plasma membrane receptors to multivesicular endosomes-They are known.

*why the LDL particle dissociates from the LDL receptor in late endosomes-known

low pH causes the LDL particles to dissociate from the LDL receptors.