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Host-derived exosomes O membrane vesicles 00 Mtb phagosome MVB Membrane vesicles Host proteins Mtb-infected macrophage PAMPs and Ag Extracellular MtbMVs TLR2 agonists LAM Dendrite Induce DC maturation & MHCHI Ag presentation macrophone Impair MHC-l expression & antigen presentation conTals Inhibit T cell activation & induce anergy
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Answer #1
  • The picture is describing about infection of a macrophage with Mycobacterium tuberculosis (Mtb).
  • Mycobacterium tuberculosis causes tuberculosis.
  • These mycobacteria are intracellular facultative parasitic organisms.
  • These mycobacteria mainly infect macrophages and monocytes.
  • The infected macrophage shows internal environmental changes providing resources for the growth and multiplication of Mtb.
  • This mycobacterial infection leads to arrest maturation of macrophages.
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