1.The KRAS gene encodes the KRAS protein which functions to promote cell growth and division. A single base-pair deletion occurs in exon 4 of the KRAS gene that results in an early stop codon. This mutation results in an unregulated KRAS protein that always sends growth signals.
What is a correct classification of the normal (wildtype) KRAS gene?
A) A tumor suppressor gene
B) An oncogene
C) A tumor activating gene
D) A DNA repair gene
E) A proto-oncogene
2. The KRAS gene encodes the KRAS protein which functions to promote cell growth and division. A single base-pair deletion occurs in exon 4 of the KRAS gene that results in an early stop codon. This mutation results in an unregulated KRAS protein that always sends growth signals.
True or False: A cell would need to have two copies of the KRAS gene mutation described above to have increased growth and division.
A) True
B) False
1. B) An oncogene. (KRAS gene belongs to the class of genes called oncogenes)
2. B) False
1.The KRAS gene encodes the KRAS protein which functions to promote cell growth and division. A...
The gene APC encodes a protein important for cell-cell adhesion and contact inhibition, the phenomenon in which cells know when to stop dividing based on interaction with neighboring cells. A mutation in APC is associated with colon cancer. How is this gene classified? a. tumor-suppressor b. passenger mutation c. gene mutation d. proto-oncogene
The dopamine transporter gene encodes a protein required to re-uptake dopamine into the pre-synaptic neuron from the synapse. How might a variant allele of the dopamine transporter gene, which results in a transporter protein with increased function , be involved in predisposing an individual to addictive behavior? A) The dopamine transporter variant allele would produce more dopamine in response to addictive behavior B) The dopamine transporter variant allele would produce less dopamine in response to addictive behavior C) The dopamine...
A cancer cell undergoes cell division in an unregulated manner (for example, when no growth factors are present). Alterations of the following factors could cause cells to exhibit such ‘uncontrolled growth’ characteristics. Determine whether the gene encoding the specified factor behaves like an oncogene/proto-oncogene or a tumor suppressor gene. Briefly explain your reasoning. A kinase that functions in a growth factor signal transduction pathway. A CDK that functions in cell cycle regulation. A kinase that functions to turn off the CDK described in...
Cancer and Gene Regulation Why is a cell cycle control system needed for cell division? What happens when cells do NOT respond to the cell cycle control system and divide excessively? Tumor Proto-oncogeno (for protein that stimulates coll division) 6 Y DNA Benign Tumor= Mutation withln a control region of DNA Malignant Tumor Mutated promoter Metastasis Normal growth-stimulating protein in excess Oncogene Tumor-Suppressor Genes Proto-oncogene utled tara gese Samor-auppresr gane Many proto-oncogenes code for growth factors /Deletive nonimenig Normel grewt...
A cell that is heterozygous for a nonsense mutation in a tumor suppressor gene would most likely: A) Group of answer choices B) grow but not divide C) have a normal cell cycle D) arrest and induce apoptosis E) have a slightly increased cell cycle and increased cell growth F) grow and divide uncontrollably Which of the following correctly describes an event that occurs during transcription: Group of answer choices A) A DNA molecule is chemically modified to become a...
Below is a schematic of gene Hemoglobin beta subunit (HBS), which
encodes protein HBS. The promoter region is indicated by the dotted
box. Transcriptions begins immediately following the promoter. The
mature mRNA produced by this gene would be approximately how many
nucleotides long?
A) 100
B) 200
C) 3000
D) 5000
E) 7000
1. Below is a schematic of gene Hemoglobin beta subunit (HBS), which encodes protein HBS. The promoter region is indicated by the dotted box. Transcription begins immediately...
The gene encoding protein Bog in E. coli has been changed by a point mutation in its open reading frame. Originally the gene encoded a 108 amino acid long functioning protein whose amino acid composition favored nonpolar and negatively charged amino acids. After the mutation it encodes a 110 amino acid long non-functioning protein that is now rich in polar uncharged amino acids and positively charged amino acids. Which mutation scenario best explains this observation. A) A frame-shift caused by...
QUESTION 1 A gene that encodes a protein that stimulates progression of the cell cycle is known as a proto-oncogene. True False QUESTION 2 Cytokinesis occurs after which stage or phase of the cell cycle? a. G2 b. S c. G0 d. G1 e. M phase QUESTION 3 During cell-cycle checkpoints, protein kinases known as CDKs phosphorylate target proteins only when they associate with a cyclin. True False QUESTION 4 During mitosis, many of the spindle fibers attach to chromosomes...
please answer all 6 questions
Question 27 3 pts TRBP is a protein important for the formation of the RISC complex. Which of the following would you expect in cells with null mutations in TRBP? o Reduced siRNA-mediated mRNA degradation o Increased miRNA-mediated translational repression o Increased deadenylase-mediated mRNA degradation o Reduced proteasome-mediated protein degradation D Question 28 3 pts A protein that binds to the 3' UTR of a VEGF mRNA and promotes deadenylation and uncapping is likely to:...
Please answer 2-5
2. Consider a gene with a particular function. Mutation X and mutation Y cach cause defects in the function of the encoded protein, yet a gene containing both mutations X and Y encodes a protein that works even better than the original protein. The odds are exceedingly small that a single mutational event will generate both mutations X and Y. Explain a simple way that an organism with a mutant gene containing both mutations X and Y...