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Which of the following would be included as relevant for toxicokinetics? a. Inactivation of ribosomes b....

Which of the following would be included as relevant for toxicokinetics?

a.

Inactivation of ribosomes

b.

Oxidation of DNA

c.

Formation of DNA adducts

d.

Renal clearance

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Answer-

d) Renal clearance would be included as relevant for toxicokinetics.

Toxicokinetics is the study of absorption, distribution, metabolism and excretion of toxicants in the body. Toxicants, mainly xenobiotics are the environmental chemicals which translocate to the body and at various sites they create damages. Translocation of toxicants is done by various processes:

A) Absorption from the site of action via skin, GI tract or lungs.

B) Transport of xenobiotics by blood to the biotransformation sites or other tissues.

C) Accumulation of xenobiotics and their release into the blood.

D) Elimination or clearance from the body mainly through GI tract and kidney.

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