Question

explain the induced-fit model of enzyme action, and how this differe from the "Lock-&-key" model

NOA HOJAVEN EN GENOSSO Questions to expand your mind. 1. Explain the Induced-Fit model of enzyme action, and how this differs from the Lock-&-Key" model. 2. Distinguish between catabolic and anabolie enzyme reactions 3. Define and describe 3 variables that may affect enzyme activity. 4. **Online Search Opportunity** What are the steps involved in commercial cheese making? Is this different from how organic farm cheese is made? Revised Version 4.5 5-6-16 Page 6 L'O=Pjuegabessaung -opaſoud WebbxzuydXNAS

Answer 1

Ans1) Lock and Key model and Induced Fit model are two models which describe the binding process between enzyme and substrate.

Lock and Key Model:

This model assumes high degree of complementarity between the binding site of the enzyme and its substrate just like a lock and its key.

It is proposed by Emil Fisher in 1894.

Induced Fit Model:

This model states that binding of the substrate causes a conformational change in the enzyme that results in a complementary fit between the enzyme and the substrate.

Difference between both the models:

According to Lock and Key model, the substrate and the binding site of the enzyme are complementary to each other before the substrate binds to the active site.

But according to Induced fit model, the active site forms a complementary shape to the substrate only after the substrate has been bound.