Question

18a. The DNA is mutated on the 4th nucleotide (see bases in box) to the follo DNA :3TAC GCT GAG AGA GAC ACTS sº ATG CGA CTC TCT CTG TGA 3» 18b. (2pts) Does this mutation change the amino acid sequence? If yes - what is 18c. (2pts) Can this mutation change the way the protein functions? 18d. (2pts) How can a DNA mutation change protein function? Explain your answer in terms of gene expression.

18 please

Answer 1

Q15b.5' AUGGGACUCUCUCUGUGA3'

Q16a.CUC is the third codon of the mRNA.

Q16b.GAG is the third anti codon.

Q16c. Leu (Leucine) is attached to tRNA.

Q18b. Yes, the mutation changes the amino acid sequence therefore the new mRNA sequence is: 5'AUGCGACUCUCUCUGUGA3' this the codon sequence for the amino acid sequence

Q18c. Yes, the mutation changes the way the protein functions because a single change in the nucleotide base leads to a change in the amino acid it codes for therefore change in a single amino acid in a long polypeptide chain leads to improper folding of the protein which is newly formed and thus leads to a truncated version of the protein.

Q18d.Since the mutation causes the truncated version of a protein this creates malfunctioning of the protein or no functioning of the protein (absence of that protein itself). Always it is not the genes that cause diseases, but the genetic disorders are result of mutations which makes the genes to function improperly. But in certain conditions there are chances for the body to rectify the problem by repair mechanisms.