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which missing single animals sit at position c and

4. Describe the factors which affect the absorption of an oral drug in the (i) stomach and (ii) small intestine. [6 marks]

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Answer #1

The factors which influence the drug absorption in the stomach are based on drug particle size, concentration, formulation, fillers, solubility and external coating and the gastric environment in the stomach namely acidic pH, gastric emptying time, ionisation state of the drug, presence of food in the stomach and the type of food.

In the small intestine, the alkaline environment, intestinal transit time, surface area available intestinal motility. gut wall enzymes and gut bacteria are the major factors influencing drug absorption. Gastric emptying rate is very important in determining the drug absorbance rate in the small intestine because the drug spends atleast 4-5 hours in the small intestine, so the drug needs to be transited from the stomach without much delay.

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