Question

Let us imagine we take a population and subject it to a programme of inbreeding by mating closely related individuals.

Let us imagine that all mutations are semi-dominant. What happens to the average fitness if we inbreed and why?

Answer 1

In breeding can effect fitness related traits at different life history stages and may interact with enviromental

to induce even larger effects.

The mutations in all alleles cause substitutions in conserved aminoacids that are located adjacent to predicted

transmembrane regions In humans dominant and semidominant diseases caused by mutations in transcription

factors,transporters and components of signaling cascades. Mutations in such genes may lead to dominant phenotype through a number of different mechanisms.

Another class of dominanat mutations either increase the abundance of stabilizes mRNA transcripts or their encoded proteins ,preventing the normal turnover of these molecules essential for the wild type phenotype

   semidominant mutations can be distinguished because they exhibit different part of inheritance. dominant mutations often lead to gain of function for example dominant mutations may increase activity of given gene product ,confer a new activity of the gene product leads to inappropriate spatial and temporal expresson.may be associated with a loss of function .