Homework Answers
Anaphase promoting complex or APC is an E3 ubiquitin ligase that regulates proteolysis of specific cell cycle proteins by the 26S proteasome. It is required to induce progression from metaphase to anaphase by the breakdown of various cell cycle regulators like securin and cyclin M and S. Destruction of securin in metaphase activates a protease that separates the sister chromatids and promotes anaphase. APC activity changes during the cell cycle, primarily as a result of changes in its association with an activating subunit either Cdc20 in mid-mitosis or Cdh1 from late mitosis through early G1. Cdc20 can only binds to APC after specific subunits are phosphorylated by the Cdk1. If a mutation that causes APC to always be phosphorylated then that cell would not complete cell cycle due to the constitutive degradation of M and S-cyclins. S cyclin stimulate chromosome duplication. M-cyclins stimulate entry into mitosis at the G2/M transition.
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a. What would happen if there was a mutation that caused APC to always be phosphorylated?...
References Mallings Review View AaBbcode Acade Aa A ELEVEREE ! PAESE Evvv No Spacing becurs, APC...
References Mallings Review View AaBbcode Acade Aa A ELEVEREE ! PAESE Evvv No Spacing becurs, APC activates two proteins, the enzyme seperase and cyclin B. APC also deactivates the cyclin-dependent kinase Cdk1. Seperase cleaves the proteins holding sister chromatids together, called _cohesion complex allowing them to separate. Cdki is dephosphorylated by a protein phosphotase an enzyme that removes a phosphate, and so the cell can exit mitosis. When it does, it will be in the phase, a part of the...
What would you expect to happen to a newly synthesized soluble protein if a mutation caused...
What would you expect to happen to a newly synthesized soluble protein if a mutation caused the deletion of the KDEL sequence? a. The protein would be returned to the ER in COPI-coated vesicles. b. The protein will be carried forward through the Golgi apparatus. c. The protein will be trapped in COPII vesicles . d. The protein will be incorporated into COPI vesicles. e. The protein will be recognized by KDEL receptors and a retrieval sequence (KDEL sequence) will...
If the mutation is in isocitrate dehydrogenase, what would you expect to happen to the levels...
If the mutation is in isocitrate dehydrogenase, what would you expect to happen to the levels of : (increase/decrease) isocitrate a- ketoglutarate glyoxylate
What would be the effects on DNA replication if mutation of DNA polymerase III caused it...
What would be the effects on DNA replication if mutation of DNA polymerase III caused it to lose each of the following activities: 1. 5' to 3' polymerase activity 2. 3' to 5' exonuclease activity:
What would happen if an allele under positive selection was linked to a deleterious mutation?(Do not...
What would happen if an allele under positive selection was linked to a deleterious mutation?(Do not copy others answers)!!
What would happen to the proton gradient created during photosynthesis if a genetic mutation rendered plastocyanin...
What would happen to the proton gradient created during photosynthesis if a genetic mutation rendered plastocyanin unable to bind electrons. MacBook Pro 8
16) What would happen if a mutation occurred in E. Coli that eliminated the production of...
16) What would happen if a mutation occurred in E. Coli that eliminated the production of the protein sigma? A) Ribosomes would no longer be able to participate in translation B) mRNA transcripts would no longer be produced C) Amino Acids could no longer be connected to one another via peptide bonds D) Introns would no longer be spliced out of MRNAs E) mRNA transcripts could not dissociate from the RNA polymerase
QUESTION 13 Which of the following would occur if a mutation caused Kinase 1 to be...
QUESTION 13
Which of the following would occur if a mutation caused Kinase 1
to be unable to be phosphorylated? (Select all)
RTK would bind VEGF
RTK would phosphorylate itself
RAS would become active
The phosphorylation cascade would occur
The endothelial cell would divide
0.2 points
QUESTION 14
Imagine that an endothelial cell has a mutation in several of
the enzymes that perform mismatch repair. The endothelial cell
replicates its DNA and then divides into two cells. The resulting...
9. What would an action potential look like if an animal had a mutation in a...
9. What would an action potential look like if an animal had a mutation in a voltage-gated potassium channel that caused it to open at -10mV instead of +40mV? Use diagrams to illustrate your answers (4 points).
Part IV—The APC Protein “Sam, I’m really worried about seeing my test results today,” Jane said...
Part IV—The APC Protein “Sam, I’m really worried about seeing my test results today,” Jane said as they headed in for another visit with their genetic counselor. “After Ms. Meeker explained your results to us, I’ve been dreading hearing whether or not I have the mutation too.” Sam nodded, saying, “I can understand how you feel. I’m glad I can be here at the appointment to support you. Whatever happens, you know your family is here for you.” Ms. Meeker...
References Mallings Review View AaBbcode Acade Aa A ELEVEREE ! PAESE Evvv No Spacing becurs, APC activates two proteins, the enzyme seperase and cyclin B. APC also deactivates the cyclin-dependent kinase Cdk1. Seperase cleaves the proteins holding sister chromatids together, called _cohesion complex allowing them to separate. Cdki is dephosphorylated by a protein phosphotase an enzyme that removes a phosphate, and so the cell can exit mitosis. When it does, it will be in the phase, a part of the...
What would happen to the proton gradient created during photosynthesis if a genetic mutation rendered plastocyanin unable to bind electrons. MacBook Pro 8
QUESTION 13
Which of the following would occur if a mutation caused Kinase 1
to be unable to be phosphorylated? (Select all)
RTK would bind VEGF
RTK would phosphorylate itself
RAS would become active
The phosphorylation cascade would occur
The endothelial cell would divide
0.2 points
QUESTION 14
Imagine that an endothelial cell has a mutation in several of
the enzymes that perform mismatch repair. The endothelial cell
replicates its DNA and then divides into two cells. The resulting...
9. What would an action potential look like if an animal had a mutation in a voltage-gated potassium channel that caused it to open at -10mV instead of +40mV? Use diagrams to illustrate your answers (4 points).
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